Postprandial lipemia and the relationship to health

Catherine E. Huggins, Maxine P. Bonham, Sarah D. Lee, Anthony P. James, Katya M. Clark

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


When the breakdown of triglyceride (TG) from chylomicrons (diet-derived TG) and very low-density lipoprotein (liver-derived TG) is impaired or delayed after a meal, there is an increased production of cholesterol-rich remnants, production of small dense low-density lipoprotein (LDL) particles, and a reduction of high-density lipoprotein (HDL). This is known as a pro-atherogenic phenotype that can lead to cardiovascular disease. There are various known and hypothesized modulators of postmeal lipid responses which are discussed in this chapter including dietary factors, meal timing, and the potential for interesterification of dietary lipids in food processing. This is followed by discussion of key nonmodifiable factors of postmeal lipid responses, including genetic factors. The evidence base to date is constrained by a wide variation in methodological approaches to assess plasma TG, which are discussed throughout the chapter to help inform future research.

Original languageEnglish
Title of host publicationAdvances in Dietary Lipids and Human Health
EditorsDuo Li
Place of PublicationLondon UK
Number of pages17
ISBN (Electronic)9780128239148
ISBN (Print)9780128242193
Publication statusPublished - 2022


  • Atherogenesis
  • Chylomicrons
  • Dietary fat
  • Dyslipidemia
  • Lipemia
  • Lipoprotein remnants
  • Postmeal
  • Triglycerides
  • Very low-density lipoprotein

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