Post-Transplantation Osteoporosis

Emily Stein, Peter Ebeling, Elizabeth Shane

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)

Abstract

Osteoporosis is prevalent in transplant recipients and is related to pre- and post-transplantation factors. Low bone density and fractures may antedate transplantation, related to traditional risk factors for osteoporosis, effects of chronic illness, and end-stage organ failure and its therapy, on the skeleton. Bone loss after transplantation is related to adverse effects of immunosuppressive drugs (glucocorticoids and calcineurin inhibitors) on bone remodeling. Newer immunosuppressive medications may permit lower doses of glucocorticoids and may be associated with decreased bone loss and fractures. Bisphosphonates are currently the most effective agents for the prevention and treatment of post-transplantation osteoporosis.

Original languageEnglish
Pages (from-to)937-963
Number of pages27
JournalEndocrinology and Metabolism Clinics of North America
Volume36
Issue number4
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes

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