Post translationally modified peptides: New targets in autoimmune disease

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There is growing evidence in the literature that post translatlonally modified proteins may be one of the key targets involved in autoimmune disease. We discuss the generality of immune recognition of modified proteins and their role in autoimmune disease and their role in rheumatoid arthritis in detail. Various studies have linked citrullinated proteins to the development of rheumatoid arthritis and multiple sclerosis. Citrullination is a post translational modification where the imine group in the arginine residues of a protein are converted to a carboxyl group to form citrulline residues. This discovery has led to the development of a test that is used to assist in the diagnosis of rheumatoid arthritis. However, more research needs to be performed to gain a greater understanding into the role of post translationally modified proteins in rheumatoid arthritis and other autoimmune syndromes so this information can be harnessed to design better treatments for these diseases.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalChimica Oggi
Publication statusPublished - 2 Aug 2007
Externally publishedYes

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