Post-translational modification (PTM) bioinformatics in China: progresses and perspectives

Liu Zexian, Cai Yudong, Guo Xuejiang, Li Ao, Li Tingting, Qiu Jianding, Ren Jian, Shi Shaoping, Jiangning Song, Wang Minghui, Xie Lu, Xue-Li Yu, Zhang Ziding, Zhao Xingming

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Abstract

Post-translational modifications (PTMs) are essential for regulating conformational changes, activities and functions of proteins, and are involved in almost all cellular pathways and processes. Identification of protein PTMs is the basis for understanding cellular and molecular mechanisms. In contrast with labor-intensive and time-consuming experiments, the PTM prediction using various bioinformatics approaches can provide accurate, convenient, and efficient strategies and generate valuable information for further experimental consideration. In this review, we summarize the current progresses made by Chineses bioinformaticians in the field of PTM Bioinformatics, including the design and improvement of computational algorithms for predicting PTM substrates and sites, design and maintenance of online and offline tools, establishment of PTM-related databases and resources, and bioinformatics analysis of PTM proteomics data. Through comparing similar studies in China and other countries, we demonstrate both advantages and limitations of current PTM bioinformatics as well as perspectives for future studies in China.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
JournalHereditas (Beijing)
Volume37
Issue number7
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

Keywords

  • post-translational modification
  • covalent modification
  • PTM proteomics
  • phosphorylation

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