Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C. Fernandes, John Toubia, Scott Townley, Adrienne R. Hanson, B. Kate Dredge, Katherine A. Pillman, Andrew G. Bert, Jean M. Winter, Richard Iggo, Rajdeep Das, Daisuke Obinata, MURAL investigators, Shahneen Sandhu, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Lisa M. Butler, Amina Zoubeidi, Philip A. Gregory, Wayne D. TilleyTheresa E. Hickey, Gregory J. Goodall, Luke A. Selth

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19 Citations (Scopus)


Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

Original languageEnglish
Article number108585
Number of pages23
JournalCell Reports
Issue number1
Publication statusPublished - 5 Jan 2021


  • FOXA1
  • lineage plasticity
  • microRNA
  • miR-194
  • neuroendocrine prostate cancer
  • post-transcriptional gene regulation
  • prostate cancer
  • transdifferentiation

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