Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice

Cai Wei Qiu, Zong Yao Liu, Feng Lan Zhang, Ling Zhang, Fan Li, Shu Yi Liu, Jian Ying He, Zhi Cheng Xiao

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cerebral ischemic stroke is one of the leading causes of death and disability worldwide, and the only available drug treatment is limited to a short window following the ischemic event. Gastrodin is the major bioactive constituent extracted from the tuber Gastrodia elata, and is currently used to treat dizziness in the clinic. “Early” application of gastrodin (before modeling or immediately after ischemic injury) has shown antioxidative and neuroprotective effects in a transient focal brain ischemia model in rodents; however, it is not known whether the delayed administration of gastrodin after permanent focal cerebral ischemia ameliorates neural injury and increases neurogenesis. In this study, we performed a permanent middle cerebral artery occlusion (MCAO) model for the study of cerebral ischemic stroke in adult male mice to examine the effects of gastrodin. Gastrodin treatment that was started “late” (one day after the ischemic injury) significantly improved neural function, reduced infarct volume and apoptosis, and increased the number of DCX/BrdU double-positive cells in permanent MCAO mice. Moreover, gastrodin treatment markedly preserved the Wnt/β-Catenin signaling pathway, which could promote neurogenesis and provide neuroprotection brain injury. Our findings suggest that gastrodin treatment following ischemic injury can induce neuroprotection, promote neurogenesis and restored the Wnt /β-Catenin signaling pathway.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalBrain Research
Volume1712
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • Brain ischemia
  • Gastrodin
  • Neurogenesis
  • Neuroprotection
  • Wnt/β-Catenin signaling pathway

Cite this

Qiu, Cai Wei ; Liu, Zong Yao ; Zhang, Feng Lan ; Zhang, Ling ; Li, Fan ; Liu, Shu Yi ; He, Jian Ying ; Xiao, Zhi Cheng. / Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice. In: Brain Research. 2019 ; Vol. 1712. pp. 7-15.
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abstract = "Cerebral ischemic stroke is one of the leading causes of death and disability worldwide, and the only available drug treatment is limited to a short window following the ischemic event. Gastrodin is the major bioactive constituent extracted from the tuber Gastrodia elata, and is currently used to treat dizziness in the clinic. “Early” application of gastrodin (before modeling or immediately after ischemic injury) has shown antioxidative and neuroprotective effects in a transient focal brain ischemia model in rodents; however, it is not known whether the delayed administration of gastrodin after permanent focal cerebral ischemia ameliorates neural injury and increases neurogenesis. In this study, we performed a permanent middle cerebral artery occlusion (MCAO) model for the study of cerebral ischemic stroke in adult male mice to examine the effects of gastrodin. Gastrodin treatment that was started “late” (one day after the ischemic injury) significantly improved neural function, reduced infarct volume and apoptosis, and increased the number of DCX/BrdU double-positive cells in permanent MCAO mice. Moreover, gastrodin treatment markedly preserved the Wnt/β-Catenin signaling pathway, which could promote neurogenesis and provide neuroprotection brain injury. Our findings suggest that gastrodin treatment following ischemic injury can induce neuroprotection, promote neurogenesis and restored the Wnt /β-Catenin signaling pathway.",
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author = "Qiu, {Cai Wei} and Liu, {Zong Yao} and Zhang, {Feng Lan} and Ling Zhang and Fan Li and Liu, {Shu Yi} and He, {Jian Ying} and Xiao, {Zhi Cheng}",
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Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice. / Qiu, Cai Wei; Liu, Zong Yao; Zhang, Feng Lan; Zhang, Ling; Li, Fan; Liu, Shu Yi; He, Jian Ying; Xiao, Zhi Cheng.

In: Brain Research, Vol. 1712, 01.06.2019, p. 7-15.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Qiu, Cai Wei

AU - Liu, Zong Yao

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AU - Zhang, Ling

AU - Li, Fan

AU - Liu, Shu Yi

AU - He, Jian Ying

AU - Xiao, Zhi Cheng

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