Post-natal imprinting: evidence from marsupials

Jessica Stringer, Andrew Pask, Geoff Shaw, Marilyn B Renfree

    Research output: Contribution to journalArticleResearchpeer-review

    12 Citations (Scopus)

    Abstract

    Genomic imprinting has been identified in therian (eutherian and marsupial) mammals but not in prototherian (monotreme) mammals. Imprinting has an important role in optimising pre-natal nutrition and growth, and most imprinted genes are expressed and imprinted in the placenta and developing fetus. In marsupials, however, the placental attachment is short-lived, and most growth and development occurs post-natally, supported by a changing milk composition tailor-made for each stage of development. Therefore there is a much greater demand on marsupial females during post-natal lactation than during pre-natal placentation, so there may be greater selection for genomic imprinting in the mammary gland than in the short-lived placenta. Recent studies in the tammar wallaby confirm the presence of genomic imprinting in nutrient-regulatory genes in the adult mammary gland. This suggests that imprinting may influence infant post-natal growth via the mammary gland as it does pre-natally via the placenta. Similarly, an increasing number of imprinted genes have been implicated in regulating feeding and nurturing behaviour in both the adult and the developing neonate/offspring in mice. Together these studies provide evidence that genomic imprinting is critical for regulating growth and subsequently the survival of offspring not only pre-natally but also post-natally.
    Original languageEnglish
    Pages (from-to)145 - 155
    Number of pages11
    JournalHeredity
    Volume113
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Cite this

    Stringer, J., Pask, A., Shaw, G., & Renfree, M. B. (2014). Post-natal imprinting: evidence from marsupials. Heredity, 113(2), 145 - 155. https://doi.org/10.1038/hdy.2014.10
    Stringer, Jessica ; Pask, Andrew ; Shaw, Geoff ; Renfree, Marilyn B. / Post-natal imprinting: evidence from marsupials. In: Heredity. 2014 ; Vol. 113, No. 2. pp. 145 - 155.
    @article{085a47b066104d98a063503d1caad839,
    title = "Post-natal imprinting: evidence from marsupials",
    abstract = "Genomic imprinting has been identified in therian (eutherian and marsupial) mammals but not in prototherian (monotreme) mammals. Imprinting has an important role in optimising pre-natal nutrition and growth, and most imprinted genes are expressed and imprinted in the placenta and developing fetus. In marsupials, however, the placental attachment is short-lived, and most growth and development occurs post-natally, supported by a changing milk composition tailor-made for each stage of development. Therefore there is a much greater demand on marsupial females during post-natal lactation than during pre-natal placentation, so there may be greater selection for genomic imprinting in the mammary gland than in the short-lived placenta. Recent studies in the tammar wallaby confirm the presence of genomic imprinting in nutrient-regulatory genes in the adult mammary gland. This suggests that imprinting may influence infant post-natal growth via the mammary gland as it does pre-natally via the placenta. Similarly, an increasing number of imprinted genes have been implicated in regulating feeding and nurturing behaviour in both the adult and the developing neonate/offspring in mice. Together these studies provide evidence that genomic imprinting is critical for regulating growth and subsequently the survival of offspring not only pre-natally but also post-natally.",
    author = "Jessica Stringer and Andrew Pask and Geoff Shaw and Renfree, {Marilyn B}",
    year = "2014",
    doi = "10.1038/hdy.2014.10",
    language = "English",
    volume = "113",
    pages = "145 -- 155",
    journal = "Heredity",
    issn = "0018-067X",
    publisher = "Nature Publishing Group",
    number = "2",

    }

    Stringer, J, Pask, A, Shaw, G & Renfree, MB 2014, 'Post-natal imprinting: evidence from marsupials', Heredity, vol. 113, no. 2, pp. 145 - 155. https://doi.org/10.1038/hdy.2014.10

    Post-natal imprinting: evidence from marsupials. / Stringer, Jessica; Pask, Andrew; Shaw, Geoff; Renfree, Marilyn B.

    In: Heredity, Vol. 113, No. 2, 2014, p. 145 - 155.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - Post-natal imprinting: evidence from marsupials

    AU - Stringer, Jessica

    AU - Pask, Andrew

    AU - Shaw, Geoff

    AU - Renfree, Marilyn B

    PY - 2014

    Y1 - 2014

    N2 - Genomic imprinting has been identified in therian (eutherian and marsupial) mammals but not in prototherian (monotreme) mammals. Imprinting has an important role in optimising pre-natal nutrition and growth, and most imprinted genes are expressed and imprinted in the placenta and developing fetus. In marsupials, however, the placental attachment is short-lived, and most growth and development occurs post-natally, supported by a changing milk composition tailor-made for each stage of development. Therefore there is a much greater demand on marsupial females during post-natal lactation than during pre-natal placentation, so there may be greater selection for genomic imprinting in the mammary gland than in the short-lived placenta. Recent studies in the tammar wallaby confirm the presence of genomic imprinting in nutrient-regulatory genes in the adult mammary gland. This suggests that imprinting may influence infant post-natal growth via the mammary gland as it does pre-natally via the placenta. Similarly, an increasing number of imprinted genes have been implicated in regulating feeding and nurturing behaviour in both the adult and the developing neonate/offspring in mice. Together these studies provide evidence that genomic imprinting is critical for regulating growth and subsequently the survival of offspring not only pre-natally but also post-natally.

    AB - Genomic imprinting has been identified in therian (eutherian and marsupial) mammals but not in prototherian (monotreme) mammals. Imprinting has an important role in optimising pre-natal nutrition and growth, and most imprinted genes are expressed and imprinted in the placenta and developing fetus. In marsupials, however, the placental attachment is short-lived, and most growth and development occurs post-natally, supported by a changing milk composition tailor-made for each stage of development. Therefore there is a much greater demand on marsupial females during post-natal lactation than during pre-natal placentation, so there may be greater selection for genomic imprinting in the mammary gland than in the short-lived placenta. Recent studies in the tammar wallaby confirm the presence of genomic imprinting in nutrient-regulatory genes in the adult mammary gland. This suggests that imprinting may influence infant post-natal growth via the mammary gland as it does pre-natally via the placenta. Similarly, an increasing number of imprinted genes have been implicated in regulating feeding and nurturing behaviour in both the adult and the developing neonate/offspring in mice. Together these studies provide evidence that genomic imprinting is critical for regulating growth and subsequently the survival of offspring not only pre-natally but also post-natally.

    UR - http://www.nature.com/hdy/journal/v113/n2/pdf/hdy201410a.pdf

    U2 - 10.1038/hdy.2014.10

    DO - 10.1038/hdy.2014.10

    M3 - Article

    VL - 113

    SP - 145

    EP - 155

    JO - Heredity

    JF - Heredity

    SN - 0018-067X

    IS - 2

    ER -