Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions

Anna E. Sexton, Christian Doerig, Darren J. Creek, Teresa G. Carvalho

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Plasmodium species are evolutionarily distant from model eukaryotes, and as a consequence they exhibit many non-canonical cellular processes. In the post-genomic era, functional "omics" disciplines (transcriptomics, proteomics, and metabolomics) have accelerated our understanding of unique aspects of the biology of malaria parasites. Functional "omics" tools, in combination with genetic manipulations, have offered new opportunities to investigate the function of previously uncharacterized genes. Knowledge of basic parasite biology is fundamental to understanding drug modes of action, mechanisms of drug resistance, and relevance of vaccine candidates. This Perspective highlights recent "omics"-based discoveries in basic biology and gene function of the most virulent human malaria parasite, Plasmodium falciparum.

Original languageEnglish
Pages (from-to)1269-1278
Number of pages10
JournalACS Infectious Diseases
Volume5
Issue number8
DOIs
Publication statusPublished - 9 Aug 2019

Keywords

  • "omics"
  • genetic manipulation
  • malaria
  • Plasmodium falciparum
  • putative genes
  • systems biology

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