Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs

Graeme R Polglase; Noah H Hillman; Jane Jane Pillow; Fook-Choe Cheah; Ilias Nitsos; Timothy Moss; Boris W Kramer; Machiko Ikegami; Suhas G Kallapur; Alan H Jobe

Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs

Graeme R Polglase, Noah H Hillman, Jane Jane Pillow, Fook-Choe Cheah, Ilias Nitsos, Timothy Moss, Boris W Kramer, Machiko Ikegami, Suhas G Kallapur, Alan H Jobe

Physiology

Research output: Contribution to journal › Article › Research › peer-review

66 Citations (Scopus)

Abstract

Positive end-expiratory pressure (PEEP) protects the lung from injury during sustained ventilation, but its role in protecting the lung from injury during the initiation of ventilation in the delivery room is not established. We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-minutes of ventilation are protective against lung injury. Operatively delivered preterm lambs (133+/-1d gestation) were randomly assigned to unventilated controls or to 1 of four 15 minute ventilation interventions: 1) VT15mL/kg, PEEP 0cmH2O, 2) VT15mL/kg, PEEP 5cmH2O, 3) VT8mL/kg, PEEP 0cmH2O and 4) VT8mL/kg, PEEP 5cmH2O. Each group was subsequently ventilated with VT

Original language	English
Pages (from-to)	517 - 522
Number of pages	6
Journal	Pediatric Research
Volume	64
Issue number	5
Publication status	Published - 2008

Cite this

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abstract = "Positive end-expiratory pressure (PEEP) protects the lung from injury during sustained ventilation, but its role in protecting the lung from injury during the initiation of ventilation in the delivery room is not established. We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-minutes of ventilation are protective against lung injury. Operatively delivered preterm lambs (133+/-1d gestation) were randomly assigned to unventilated controls or to 1 of four 15 minute ventilation interventions: 1) VT15mL/kg, PEEP 0cmH2O, 2) VT15mL/kg, PEEP 5cmH2O, 3) VT8mL/kg, PEEP 0cmH2O and 4) VT8mL/kg, PEEP 5cmH2O. Each group was subsequently ventilated with VT",

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AU - Polglase, Graeme R

AU - Hillman, Noah H

AU - Pillow, Jane Jane

AU - Cheah, Fook-Choe

AU - Nitsos, Ilias

AU - Moss, Timothy

AU - Kramer, Boris W

AU - Ikegami, Machiko

AU - Kallapur, Suhas G

AU - Jobe, Alan H

PY - 2008

Y1 - 2008

N2 - Positive end-expiratory pressure (PEEP) protects the lung from injury during sustained ventilation, but its role in protecting the lung from injury during the initiation of ventilation in the delivery room is not established. We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-minutes of ventilation are protective against lung injury. Operatively delivered preterm lambs (133+/-1d gestation) were randomly assigned to unventilated controls or to 1 of four 15 minute ventilation interventions: 1) VT15mL/kg, PEEP 0cmH2O, 2) VT15mL/kg, PEEP 5cmH2O, 3) VT8mL/kg, PEEP 0cmH2O and 4) VT8mL/kg, PEEP 5cmH2O. Each group was subsequently ventilated with VT

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M3 - Article

SN - 0031-3998

VL - 64

SP - 517

EP - 522

JO - Pediatric Research

JF - Pediatric Research

IS - 5

ER -

Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs

Abstract

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