Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs

Graeme R Polglase, Noah H Hillman, Jane Jane Pillow, Fook-Choe Cheah, Ilias Nitsos, Timothy Moss, Boris W Kramer, Machiko Ikegami, Suhas G Kallapur, Alan H Jobe

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Positive end-expiratory pressure (PEEP) protects the lung from injury during sustained ventilation, but its role in protecting the lung from injury during the initiation of ventilation in the delivery room is not established. We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-minutes of ventilation are protective against lung injury. Operatively delivered preterm lambs (133+/-1d gestation) were randomly assigned to unventilated controls or to 1 of four 15 minute ventilation interventions: 1) VT15mL/kg, PEEP 0cmH2O, 2) VT15mL/kg, PEEP 5cmH2O, 3) VT8mL/kg, PEEP 0cmH2O and 4) VT8mL/kg, PEEP 5cmH2O. Each group was subsequently ventilated with VT
Original languageEnglish
Pages (from-to)517 - 522
Number of pages6
JournalPediatric Research
Issue number5
Publication statusPublished - 2008

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