Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?

David Kara, Anna Hüsing-Kabar, Hartmut Schmidt, Inga Grünewald, Gursimran Chandhok, Miriam Maschmeier, Iyad Kabar

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13 Citations (Scopus)

Abstract

Background. Portal hypertension is a serious complication of liver cirrhosis. Objective. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. Methods. This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. Results. A total of 1,045 upper endoscopies were analyzed. Portal hypertensive gastric and duodenal polyps were frequently observed and were associated with thrombocytopenia (p = 0.040; OR: 2.4, 95% CI 1.04-5.50), Child-Pugh score > 6 (p = 0.033; OR: 2.3, 95% CI 1.07-4.92), Model for End Stage Liver Disease score > 16 (p = 0.030; OR: 4.1, 95% CI 1.14-15.00), and previous rubber band ligation (p < 0.001; OR = 5.2, 95% CI 2.5-10.7). These polyps often recurred after polypectomy; however, no malignant transformation occurred during the observational time until October 2017. The most common endoscopic finding was esophageal varices, observed in more than 90% of patients. Conclusion. Portal hypertensive polyposis is common in patients with advanced cirrhosis. Our data suggest that these polyps have benign characteristics.

Original languageEnglish
Article number2182784
Number of pages7
JournalCanadian Journal of Gastroenterology and Hepatology
Volume2018
DOIs
Publication statusPublished - 1 Aug 2018

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