Portal hypertension: Pathophysiology, diagnosis and management

Stephen Bloom, W. Kemp, J. Lubel

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)


Portal hypertension is an important complication of liver disease. As a result of elevated pressures within the portal vein several complications can arise, including the development of oesophageal and gastric varices, ascites, hepatic encephalopathy as well as complications secondary to circulatory dysfunction, such as hepatorenal syndrome, portopulmonary syndrome and hepatopulmonary syndrome. This review outlines the pathogenesis and diagnosis of portal hypertension and outlines the management of these various important clinical sequelae. The management of oesophageal and gastric varices is particularly important, and both the emergency management together with prophylactic management of this condition are described.

Original languageEnglish
Pages (from-to)16-26
Number of pages11
JournalInternal Medicine Journal
Issue number1
Publication statusPublished - 1 Jan 2015


  • Ascites
  • Cirrhosis
  • Encephalopathy
  • Portal hypertension
  • Varices

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