Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications

De-Xiang Zhang, Lars Esser, Roshan B. Vasani, Helmut Thissen, Nicolas H. Voelcker

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on recent advances in surface modification of pSi for controlled drug delivery applications. A range of functionalization strategies and fabrication methods for pSi-polymer hybrids are summarized. Surface engineering solutions such as stimuli-responsive polymer grafting, stealth coatings and active targeting modifications are highlighted as examples to demonstrate what can be achieved. Finally, the current status of engineered pSi nanomaterials for in vivo applications is reviewed and future prospects and challenges in drug-delivery applications are discussed.

Original languageEnglish
Pages (from-to)3213-3230
Number of pages18
JournalNanomedicine
Volume14
Issue number24
DOIs
Publication statusPublished - Dec 2019

Keywords

  • active targeting
  • drug delivery
  • in vivo application
  • porous silicon
  • pSi-polymer hybrids
  • stealth coating
  • stimuli-responsive
  • surface modification

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