Porous silicon nanodiscs for targeted drug delivery

Hashim Alhmoud, Bahman Delalat, Roey Elnathan, Anna Cifuentes-Rius, Arnaud Chaix, Mary-Louise Rogers, Jean Olivier Durand, Nicolas H. Voelcker

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Abstract

There is a strong demand for techniques that allow the fabrication of biocompatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size- and shape-controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal-assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus-prepared nanocarriers are found to selectively attach to and kill cancer cells.

Original languageEnglish
Pages (from-to)1137-1145
Number of pages9
JournalAdvanced Functional Materials
Volume25
Issue number7
DOIs
Publication statusPublished - 18 Feb 2015
Externally publishedYes

Cite this

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Porous silicon nanodiscs for targeted drug delivery. / Alhmoud, Hashim; Delalat, Bahman; Elnathan, Roey; Cifuentes-Rius, Anna; Chaix, Arnaud; Rogers, Mary-Louise; Durand, Jean Olivier; Voelcker, Nicolas H.

In: Advanced Functional Materials, Vol. 25, No. 7, 18.02.2015, p. 1137-1145.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Alhmoud, Hashim

AU - Delalat, Bahman

AU - Elnathan, Roey

AU - Cifuentes-Rius, Anna

AU - Chaix, Arnaud

AU - Rogers, Mary-Louise

AU - Durand, Jean Olivier

AU - Voelcker, Nicolas H.

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AB - There is a strong demand for techniques that allow the fabrication of biocompatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size- and shape-controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal-assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus-prepared nanocarriers are found to selectively attach to and kill cancer cells.

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