Abstract
Unlike conventional controlled drug delivery systems where drug is released at a constant pre-programmed rate, drug release from conducting polymers (CPs) can be controlled through electrical stimuli and adjusted based on the patient's needs. However, owing to their low drug loading capacity and limited electrical responsiveness CP systems cannot currently be applied for systemic drug delivery or to treat chronic disease. To overcome that obstacle one approach is to fabricate porous CP structures. In this work, polypyrrole (PPy) was used owing to its electrical responsiveness and biocompatibility. Liquid crystals were used as a template through which PPy was grown. Dexamethasone phosphate was loaded as a dopant into PPy during polymerisation and its release was quantified by HPLC after the removal of liquid crystal; release could be modified by electrical stimulus. This system has potential applications in conditions where required drug dosing changes with time, such as in age-related macular degeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 422-431 |
| Number of pages | 10 |
| Journal | International Journal of Nanotechnology |
| Volume | 14 |
| Issue number | 1-6 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- Conducting polymer
- Lyotropic liquid crystal
- Phase transition
- Polypyrrole
- SAXS
- Scanning electron microscopy
- SEM
- Small angle X-ray scattering
- Stimuli responsive drug delivery system
Cite this
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Porous conducting polymer prepared through liquid crystal template for drug delivery. / Uppalapati, Dedeepya; Boyd, Ben; Travas-Sejdic, Jadranka; Svirskis, Darren.
In: International Journal of Nanotechnology, Vol. 14, No. 1-6, 2017, p. 422-431.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Porous conducting polymer prepared through liquid crystal template for drug delivery
AU - Uppalapati, Dedeepya
AU - Boyd, Ben
AU - Travas-Sejdic, Jadranka
AU - Svirskis, Darren
PY - 2017
Y1 - 2017
N2 - Unlike conventional controlled drug delivery systems where drug is released at a constant pre-programmed rate, drug release from conducting polymers (CPs) can be controlled through electrical stimuli and adjusted based on the patient's needs. However, owing to their low drug loading capacity and limited electrical responsiveness CP systems cannot currently be applied for systemic drug delivery or to treat chronic disease. To overcome that obstacle one approach is to fabricate porous CP structures. In this work, polypyrrole (PPy) was used owing to its electrical responsiveness and biocompatibility. Liquid crystals were used as a template through which PPy was grown. Dexamethasone phosphate was loaded as a dopant into PPy during polymerisation and its release was quantified by HPLC after the removal of liquid crystal; release could be modified by electrical stimulus. This system has potential applications in conditions where required drug dosing changes with time, such as in age-related macular degeneration.
AB - Unlike conventional controlled drug delivery systems where drug is released at a constant pre-programmed rate, drug release from conducting polymers (CPs) can be controlled through electrical stimuli and adjusted based on the patient's needs. However, owing to their low drug loading capacity and limited electrical responsiveness CP systems cannot currently be applied for systemic drug delivery or to treat chronic disease. To overcome that obstacle one approach is to fabricate porous CP structures. In this work, polypyrrole (PPy) was used owing to its electrical responsiveness and biocompatibility. Liquid crystals were used as a template through which PPy was grown. Dexamethasone phosphate was loaded as a dopant into PPy during polymerisation and its release was quantified by HPLC after the removal of liquid crystal; release could be modified by electrical stimulus. This system has potential applications in conditions where required drug dosing changes with time, such as in age-related macular degeneration.
KW - Conducting polymer
KW - Lyotropic liquid crystal
KW - Phase transition
KW - Polypyrrole
KW - SAXS
KW - Scanning electron microscopy
KW - SEM
KW - Small angle X-ray scattering
KW - Stimuli responsive drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=85014086261&partnerID=8YFLogxK
U2 - 10.1504/IJNT.2017.082462
DO - 10.1504/IJNT.2017.082462
M3 - Article
VL - 14
SP - 422
EP - 431
JO - International Journal of Nanotechnology
JF - International Journal of Nanotechnology
SN - 1475-7435
IS - 1-6
ER -