Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Haruka Sakaue, Takuya Shiota, Naoya Ishizaka, Shin Kawano, Yasushi Tamura, Kher Shing Tan, Kenichiro Imai, Chie Motono, Takatsugu Hirokawa, Kentaro Taki, Non Miyata, Osamu Kuge, Trevor Lithgow, Toshiya Endo

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26 Citations (Scopus)


The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6.

Original languageEnglish
Pages (from-to)1044-1055
Number of pages12
JournalMolecular Cell
Issue number5
Publication statusPublished - 7 Mar 2019


  • mitochondria
  • porin
  • protein import
  • TOM complex
  • Tom22
  • Tom40
  • Tom6
  • VDAC

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