Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Haruka Sakaue; Takuya Shiota; Naoya Ishizaka; Shin Kawano; Yasushi Tamura; Kher Shing Tan; Kenichiro Imai; Chie Motono; Takatsugu Hirokawa; Kentaro Taki; Non Miyata; Osamu Kuge; Trevor Lithgow; Toshiya Endo

doi:10.1016/j.molcel.2019.01.003

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Haruka Sakaue, Takuya Shiota, Naoya Ishizaka, Shin Kawano, Yasushi Tamura, Kher Shing Tan, Kenichiro Imai, Chie Motono, Takatsugu Hirokawa, Kentaro Taki, Non Miyata, Osamu Kuge, Trevor Lithgow, Toshiya Endo

Research output: Contribution to journal › Article › Research › peer-review

45 Citations (Scopus)

Abstract

The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6.

Original language	English
Pages (from-to)	1044-1055
Number of pages	12
Journal	Molecular Cell
Volume	73
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.01.003
Publication status	Published - 7 Mar 2019

Keywords

mitochondria
porin
protein import
TOM complex
Tom22
Tom40
Tom6
VDAC

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10.1016/j.molcel.2019.01.003

Cite this

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title = "Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly",

abstract = "The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6.",

keywords = "mitochondria, porin, protein import, TOM complex, Tom22, Tom40, Tom6, VDAC",

author = "Haruka Sakaue and Takuya Shiota and Naoya Ishizaka and Shin Kawano and Yasushi Tamura and Tan, {Kher Shing} and Kenichiro Imai and Chie Motono and Takatsugu Hirokawa and Kentaro Taki and Non Miyata and Osamu Kuge and Trevor Lithgow and Toshiya Endo",

year = "2019",

month = mar,

day = "7",

doi = "10.1016/j.molcel.2019.01.003",

language = "English",

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pages = "1044--1055",

journal = "Molecular Cell",

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T1 - Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

AU - Sakaue, Haruka

AU - Shiota, Takuya

AU - Ishizaka, Naoya

AU - Kawano, Shin

AU - Tamura, Yasushi

AU - Tan, Kher Shing

AU - Imai, Kenichiro

AU - Motono, Chie

AU - Hirokawa, Takatsugu

AU - Taki, Kentaro

AU - Miyata, Non

AU - Kuge, Osamu

AU - Lithgow, Trevor

AU - Endo, Toshiya

PY - 2019/3/7

Y1 - 2019/3/7

N2 - The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6.

AB - The mitochondrial protein entry gate, the TOM complex, undergoes a dynamic conversion between the fully assembled trimer and the dimer lacking Tom22. Mitochondrial porin, Por1, regulates the trimer assembly by chaperoning newly imported Tom22 and dimer-trimer dependent functions of the TOM complex together with Tom6.

KW - mitochondria

KW - porin

KW - protein import

KW - TOM complex

KW - Tom22

KW - Tom40

KW - Tom6

KW - VDAC

UR - http://www.scopus.com/inward/record.url?scp=85062245901&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.01.003

DO - 10.1016/j.molcel.2019.01.003

M3 - Article

AN - SCOPUS:85062245901

SN - 1097-2765

VL - 73

SP - 1044

EP - 1055

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Abstract

Keywords

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The molecular blue-print for a mitochondrial nanomachine

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Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Abstract

Keywords

Access to Document

Other files and links

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The molecular blue-print for a mitochondrial nanomachine

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