Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: Simulation of doses according to renal function

Janna K Duong, Shaun S Kumar, Carl Michael James Kirkpatrick, Louise Greenup, Manit Arora, Toong C Lee, Peter Timmins, Garry G Graham, Timothy J Furlong, Jerry R Greenfield, Kenneth M Williams, Richard O Day

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Abstract

The population model enabled doses of metformin to be simulated for each stage of renal function, to ensure the concentrations of metformin do not exceed 5 mg/l. However, the plasma concentrations of metformin at these dosage levels are still quite variable and monitoring metformin concentrations may be of value in individualising dosage. This study provides confirmatory data that metformin can be used, with appropriate dosage adjustment, in patients with renal impairment.
Original languageEnglish
Pages (from-to)373 - 384
Number of pages12
JournalClinical Pharmacokinetics
Volume52
DOIs
Publication statusPublished - 2013

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