Population pharmacokinetics of a novel histone deacetylase inhibitor, cyclo{(2S)-2-amino-8-[(aminocarbonyl)hydrazono] decanoyl-1-L-tryptophyl-L- isoleucyl-(2R)-2-piperidinecarbonyl} (SD-2007) and its metabolic conversion to apicidin after...

Beom Shin, Jurgen Bulitta, Deok Hong, Hye Kim, Min Kim, Yohan Choi, Jong Lee, Sang Hwang, Mann Lee, Sun Yoo

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This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats.
Original languageEnglish
Pages (from-to)259 - 267
Number of pages9
Issue number3
Publication statusPublished - 2011

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