Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm

A. B. Ruzilawati, Mohd Suhaimi Ab Wahab, S. H. Gan

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Objective: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide's serum concentration determination by using high-performance liquid chromatography. The parametric Iterative Two-Stage Bayesian Population Model (it2b) program followed by the Non-Parametric Adaptive Grid (npag) program was used to determine a population pharmacokinetic modelling of repaglinide. Results: Using the npag program, the mean elimination rate constant (kel) of repaglinide was 0·58 ± 0·27 h and the volume of distribution (Vd) was 23·09 ± 9·19 Lh. Conclusion: In this first report, specifically on the population pharmacokinetic modelling of repaglinide, the data generated should help us to better understand appropriate dosage-regimens for the drug.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalJournal of Clinical Pharmacy and Therapeutics
Volume35
Issue number1
DOIs
Publication statusPublished - 1 Feb 2010
Externally publishedYes

Keywords

  • It2b
  • Npag
  • Population pharmacokinetic modelling
  • Repaglinide

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