Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Christopher H. Heath; Monica A. Slavin; Tania C. Sorrell; R. Handke; A. Harun; M. Phillips; Quoc Nguyen; L. Delhaes; David Ellis; Wieland Meyer; Sharon C.A. Chen; Peter Collignon; Richard Benn; Ian Chambers; Nelson Dennis; Deo DeWit; John Ferguson; Iain Gosbell; Thomas Gottlieb; Catriona Halliday; Juliette Holland; Alison Kesson; Richard Lawrence; Deborah Marriott; Peter Newton; Pam Palasanthrian; Robert Pickles; Bob Pritchard; Lex Tierney; Voula Tomasotos; Rob Vaz; Kerry Weeks; Bart Currie; Anthony Allworth; Christopher Coulter; Joan Faoagali; Barbara Johnson; David Looke; Joseph McCormack; Graeme Nimmo; Gabrielle O'Kane; E. Geoffrey Playford; Jennifer Robson; Karen Rowlands; David Shaw; Louise Cooley; Erica Cox; Alistair McGregor; Clare Franklin; Tony Korman; Orla Morrissey; Denis Spelman; Bryan Speed; Peter Boan; John Dyer; Dianne Gardam; Duncan McLennan; Ronan Murray; Todd Pryce; on behalf of the Australian Scedosporium Study Group

doi:10.1111/j.1469-0691.2009.02802.x

Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Christopher H. Heath, Monica A. Slavin, Tania C. Sorrell, R. Handke, A. Harun, M. Phillips, Quoc Nguyen, L. Delhaes, David Ellis, Wieland Meyer, Sharon C.A. Chen, Peter Collignon, Richard Benn, Ian Chambers, Nelson Dennis, Deo DeWit, John Ferguson, Iain Gosbell, Thomas Gottlieb, Catriona HallidayJuliette Holland, Alison Kesson, Richard Lawrence, Deborah Marriott, Peter Newton, Pam Palasanthrian, Robert Pickles, Bob Pritchard, Lex Tierney, Voula Tomasotos, Rob Vaz, Kerry Weeks, Bart Currie, Anthony Allworth, Christopher Coulter, Joan Faoagali, Barbara Johnson, David Looke, Joseph McCormack, Graeme Nimmo, Gabrielle O'Kane, E. Geoffrey Playford, Jennifer Robson, Karen Rowlands, David Shaw, Louise Cooley, Erica Cox, Alistair McGregor, Clare Franklin, Tony Korman, Orla Morrissey, Denis Spelman, Bryan Speed, Peter Boan, John Dyer, Dianne Gardam, Duncan McLennan, Ronan Murray, Todd Pryce, on behalf of the Australian Scedosporium Study Group

Research output: Contribution to journal › Article › Research › peer-review

108 Citations (Scopus)

Abstract

Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.

Original language	English
Pages (from-to)	689-693
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	15
Issue number	7
DOIs	https://doi.org/10.1111/j.1469-0691.2009.02802.x
Publication status	Published - 1 Jan 2009

Keywords

Epidemiology
Scedosporium
Scedosporium aurantiacum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2009.02802.x

Cite this

Heath, C. H., Slavin, M. A., Sorrell, T. C., Handke, R., Harun, A., Phillips, M., Nguyen, Q., Delhaes, L., Ellis, D., Meyer, W., Chen, S. C. A., Collignon, P., Benn, R., Chambers, I., Dennis, N., DeWit, D., Ferguson, J., Gosbell, I., Gottlieb, T., ... on behalf of the Australian Scedosporium Study Group (2009). Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. Clinical Microbiology and Infection, 15(7), 689-693. https://doi.org/10.1111/j.1469-0691.2009.02802.x

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title = "Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection",

abstract = "Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.",

keywords = "Epidemiology, Scedosporium, Scedosporium aurantiacum",

author = "Heath, {Christopher H.} and Slavin, {Monica A.} and Sorrell, {Tania C.} and R. Handke and A. Harun and M. Phillips and Quoc Nguyen and L. Delhaes and David Ellis and Wieland Meyer and Chen, {Sharon C.A.} and Peter Collignon and Richard Benn and Ian Chambers and Nelson Dennis and Deo DeWit and John Ferguson and Iain Gosbell and Thomas Gottlieb and Catriona Halliday and Juliette Holland and Alison Kesson and Richard Lawrence and Deborah Marriott and Peter Newton and Pam Palasanthrian and Robert Pickles and Bob Pritchard and Lex Tierney and Voula Tomasotos and Rob Vaz and Kerry Weeks and Bart Currie and Anthony Allworth and Christopher Coulter and Joan Faoagali and Barbara Johnson and David Looke and Joseph McCormack and Graeme Nimmo and Gabrielle O'Kane and Playford, {E. Geoffrey} and Jennifer Robson and Karen Rowlands and David Shaw and Louise Cooley and Erica Cox and Alistair McGregor and Clare Franklin and Tony Korman and Orla Morrissey and Denis Spelman and Bryan Speed and Peter Boan and John Dyer and Dianne Gardam and Duncan McLennan and Ronan Murray and Todd Pryce and {on behalf of the Australian Scedosporium Study Group}",

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language = "English",

volume = "15",

pages = "689--693",

journal = "Clinical Microbiology and Infection",

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Heath, CH, Slavin, MA, Sorrell, TC, Handke, R, Harun, A, Phillips, M, Nguyen, Q, Delhaes, L, Ellis, D, Meyer, W, Chen, SCA, Collignon, P, Benn, R, Chambers, I, Dennis, N, DeWit, D, Ferguson, J, Gosbell, I, Gottlieb, T, Halliday, C, Holland, J, Kesson, A, Lawrence, R, Marriott, D, Newton, P, Palasanthrian, P, Pickles, R, Pritchard, B, Tierney, L, Tomasotos, V, Vaz, R, Weeks, K, Currie, B, Allworth, A, Coulter, C, Faoagali, J, Johnson, B, Looke, D, McCormack, J, Nimmo, G, O'Kane, G, Playford, EG, Robson, J, Rowlands, K, Shaw, D, Cooley, L, Cox, E, McGregor, A, Franklin, C, Korman, T , Morrissey, O, Spelman, D, Speed, B, Boan, P, Dyer, J, Gardam, D, McLennan, D, Murray, R, Pryce, T & on behalf of the Australian Scedosporium Study Group 2009, 'Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection', Clinical Microbiology and Infection, vol. 15, no. 7, pp. 689-693. https://doi.org/10.1111/j.1469-0691.2009.02802.x

Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. / Heath, Christopher H.; Slavin, Monica A.; Sorrell, Tania C. et al.
In: Clinical Microbiology and Infection, Vol. 15, No. 7, 01.01.2009, p. 689-693.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Population-based surveillance for scedosporiosis in Australia

T2 - Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

AU - Heath, Christopher H.

AU - Slavin, Monica A.

AU - Sorrell, Tania C.

AU - Handke, R.

AU - Harun, A.

AU - Phillips, M.

AU - Nguyen, Quoc

AU - Delhaes, L.

AU - Ellis, David

AU - Meyer, Wieland

AU - Chen, Sharon C.A.

AU - Collignon, Peter

AU - Benn, Richard

AU - Chambers, Ian

AU - Dennis, Nelson

AU - DeWit, Deo

AU - Ferguson, John

AU - Gosbell, Iain

AU - Gottlieb, Thomas

AU - Halliday, Catriona

AU - Holland, Juliette

AU - Kesson, Alison

AU - Lawrence, Richard

AU - Marriott, Deborah

AU - Newton, Peter

AU - Palasanthrian, Pam

AU - Pickles, Robert

AU - Pritchard, Bob

AU - Tierney, Lex

AU - Tomasotos, Voula

AU - Vaz, Rob

AU - Weeks, Kerry

AU - Currie, Bart

AU - Allworth, Anthony

AU - Coulter, Christopher

AU - Faoagali, Joan

AU - Johnson, Barbara

AU - Looke, David

AU - McCormack, Joseph

AU - Nimmo, Graeme

AU - O'Kane, Gabrielle

AU - Playford, E. Geoffrey

AU - Robson, Jennifer

AU - Rowlands, Karen

AU - Shaw, David

AU - Cooley, Louise

AU - Cox, Erica

AU - McGregor, Alistair

AU - Franklin, Clare

AU - Korman, Tony

AU - Morrissey, Orla

AU - Spelman, Denis

AU - Speed, Bryan

AU - Boan, Peter

AU - Dyer, John

AU - Gardam, Dianne

AU - McLennan, Duncan

AU - Murray, Ronan

AU - Pryce, Todd

AU - on behalf of the Australian Scedosporium Study Group

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.

AB - Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.

KW - Epidemiology

KW - Scedosporium

KW - Scedosporium aurantiacum

UR - http://www.scopus.com/inward/record.url?scp=68249159677&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2009.02802.x

DO - 10.1111/j.1469-0691.2009.02802.x

M3 - Article

C2 - 19549223

AN - SCOPUS:68249159677

SN - 1198-743X

VL - 15

SP - 689

EP - 693

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 7

ER -

Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Abstract

Keywords

UN SDGs

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