Population-based surveillance for scedosporiosis in Australia

Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Christopher H. Heath, Monica A. Slavin, Tania C. Sorrell, R. Handke, A. Harun, M. Phillips, Quoc Nguyen, L. Delhaes, David Ellis, Wieland Meyer, Sharon C.A. Chen, on behalf of the Australian Scedosporium Study Group

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Abstract

Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalClinical Microbiology and Infection
Volume15
Issue number7
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Epidemiology
  • Scedosporium
  • Scedosporium aurantiacum

Cite this

Heath, C. H., Slavin, M. A., Sorrell, T. C., Handke, R., Harun, A., Phillips, M., ... on behalf of the Australian Scedosporium Study Group (2009). Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. Clinical Microbiology and Infection, 15(7), 689-693. https://doi.org/10.1111/j.1469-0691.2009.02802.x
Heath, Christopher H. ; Slavin, Monica A. ; Sorrell, Tania C. ; Handke, R. ; Harun, A. ; Phillips, M. ; Nguyen, Quoc ; Delhaes, L. ; Ellis, David ; Meyer, Wieland ; Chen, Sharon C.A. ; on behalf of the Australian Scedosporium Study Group. / Population-based surveillance for scedosporiosis in Australia : Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. In: Clinical Microbiology and Infection. 2009 ; Vol. 15, No. 7. pp. 689-693.
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abstract = "Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6{\%}) cases of colonization and 62 (34.4{\%}) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8{\%} and malignancy in 21.7{\%} of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41{\%}) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59{\%}) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8{\%}) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum.",
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Heath, CH, Slavin, MA, Sorrell, TC, Handke, R, Harun, A, Phillips, M, Nguyen, Q, Delhaes, L, Ellis, D, Meyer, W, Chen, SCA & on behalf of the Australian Scedosporium Study Group 2009, 'Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection', Clinical Microbiology and Infection, vol. 15, no. 7, pp. 689-693. https://doi.org/10.1111/j.1469-0691.2009.02802.x

Population-based surveillance for scedosporiosis in Australia : Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. / Heath, Christopher H.; Slavin, Monica A.; Sorrell, Tania C.; Handke, R.; Harun, A.; Phillips, M.; Nguyen, Quoc; Delhaes, L.; Ellis, David; Meyer, Wieland; Chen, Sharon C.A.; on behalf of the Australian Scedosporium Study Group.

In: Clinical Microbiology and Infection, Vol. 15, No. 7, 01.01.2009, p. 689-693.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Johnson, Barbara

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