TY - JOUR
T1 - Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants
AU - Kanki, Monica
AU - Nath, Artika P.
AU - Xiang, Ruidong
AU - Yiallourou, Stephanie
AU - Fuller, Peter J.
AU - Cole, Timothy J.
AU - Cánovas, Rodrigo
AU - Young, Morag J.
N1 - Funding Information:
This research was conducted using the UK Biobank Resource ( https://www.ukbiobank.ac.uk/ ) under application number 55469. This study was supported in part by the Research Training Program (RTP) Stipend PhD scholarship from Monash University (2020) (MK) and M.J.Y. is supported by the Alice Baker and Eleanor Shaw Gender Equity Fellowship, Baker Trustees. The Baker Heart and Diabetes Institute and Hudson Institute of Medical Research are supported by the Victorian Government’s Operational Infrastructure Scheme.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/11/4
Y1 - 2023/11/4
N2 - Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biobank cohort, we evaluate the association between circadian rhythm-disrupting behaviours, blood pressure (SBP, DBP) and inflammatory markers in >350,000 adults with European white British ancestry. The independent U-shaped relationship between sleep length and SBP/DBP is most prominent with a low inflammatory status. Poor sleep quality and permanent night shift work are also positively associated with SBP/DBP. Although fully adjusting for BMI in the linear regression model attenuated effect sizes, these associations remain significant. Two-sample Mendelian Randomisation (MR) analyses support a potential causal effect of long sleep, short sleep, chronotype, daytime napping and sleep duration on SBP/DBP. Thus, in the current study, we present a positive association between circadian rhythm-disrupting behaviours and SBP/DBP regulation in males and females that is largely independent of age.
AB - Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biobank cohort, we evaluate the association between circadian rhythm-disrupting behaviours, blood pressure (SBP, DBP) and inflammatory markers in >350,000 adults with European white British ancestry. The independent U-shaped relationship between sleep length and SBP/DBP is most prominent with a low inflammatory status. Poor sleep quality and permanent night shift work are also positively associated with SBP/DBP. Although fully adjusting for BMI in the linear regression model attenuated effect sizes, these associations remain significant. Two-sample Mendelian Randomisation (MR) analyses support a potential causal effect of long sleep, short sleep, chronotype, daytime napping and sleep duration on SBP/DBP. Thus, in the current study, we present a positive association between circadian rhythm-disrupting behaviours and SBP/DBP regulation in males and females that is largely independent of age.
UR - http://www.scopus.com/inward/record.url?scp=85175848882&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-42758-6
DO - 10.1038/s41467-023-42758-6
M3 - Article
C2 - 37925459
AN - SCOPUS:85175848882
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 7096
ER -
