Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C

Mark Walterfang; Matthew D Macfarlane; Jeffrey Chee Leong Looi; Larry Abel; Elizabeth Bowman; Michael Collingwood Fahey; P M Desmond; Dennis Velakoulis

doi:10.1111/j.1468-1331.2011.03545.x

Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C

Mark Walterfang, Matthew D Macfarlane, Jeffrey Chee Leong Looi, Larry Abel, Elizabeth Bowman, Michael Collingwood Fahey, P M Desmond, Dennis Velakoulis

Paediatrics Monash Health

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

Niemann-Pick disease type C (NPC) is a preogressive neurovisceral disorder associated with dystonia, ataxia and a characteristic gaze palsy. Our aim was to utilize a method for brainstem atrophy, validated in progressive supranuclear palsy (PSP), in a group of adult patients with NPC, and explore its relationship to illness variables and ocular-motor functioning.

Original language	English
Pages (from-to)	462 - 467
Number of pages	6
Journal	European Journal of Neurology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1111/j.1468-1331.2011.03545.x
Publication status	Published - 2012

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10.1111/j.1468-1331.2011.03545.x

Cite this

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title = "Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C",

abstract = "Niemann-Pick disease type C (NPC) is a preogressive neurovisceral disorder associated with dystonia, ataxia and a characteristic gaze palsy. Our aim was to utilize a method for brainstem atrophy, validated in progressive supranuclear palsy (PSP), in a group of adult patients with NPC, and explore its relationship to illness variables and ocular-motor functioning.",

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AU - Walterfang, Mark

AU - Macfarlane, Matthew D

AU - Looi, Jeffrey Chee Leong

AU - Abel, Larry

AU - Bowman, Elizabeth

AU - Fahey, Michael Collingwood

AU - Desmond, P M

AU - Velakoulis, Dennis

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AB - Niemann-Pick disease type C (NPC) is a preogressive neurovisceral disorder associated with dystonia, ataxia and a characteristic gaze palsy. Our aim was to utilize a method for brainstem atrophy, validated in progressive supranuclear palsy (PSP), in a group of adult patients with NPC, and explore its relationship to illness variables and ocular-motor functioning.

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DO - 10.1111/j.1468-1331.2011.03545.x

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VL - 19

SP - 462

EP - 467

JO - European Journal of Neurology

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