Polyunsaturated fatty acid intake and blood pressure in adolescents

T. A. O'Sullivan, A. P. Bremner, L. J. Beilin, Gina L. Ambrosini, T. A. Mori, R. C. Huang, Wendy H. Oddy

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Evidence that intake of polyunsaturated fatty acids (PUFAs) may modify blood pressure (BP) is generally limited to middle-aged or hypertensive populations. This study examined cross-sectional associations between BP and dietary intake of PUFAs in 814 adolescents aged 13-15 years participating in the Western Australian Pregnancy Cohort (Raine) Study. Fatty acid intakes were assessed using 3-day diet records and resting BP was determined using multiple oscillometric readings. In multivariate regression models, systolic BP was inversely associated with intakes of polyunsaturated (b0.436, P0.01), omega-3 (b2.47, P0.02), omega-6 (b0.362, P0.04) and long chain omega-3 fatty acids (b4.37, P0.04) in boys. Diastolic BP and mean arterial pressure were inversely associated with intakes of long chain omega-3 fatty acids in boys (b3.93, P0.01, b4.05, P0.01, respectively). For specific long-chain omega-3s, significant inverse associations were observed between eicosapentaenoic acid (EPA) and docosahexaenoic acid, such as systolic BP decreasing by 4.7 mm Hg (95% CI-9.3 to 0.1) for a quarter gram increase in EPA, but no significant associations were observed with docosapentaenoic acid. No significant associations were observed in girls, or with the omega-6 to omega-3 ratio. Our results suggest that gender may moderate relationships between fatty acid intake and BP in adolescence.

Original languageEnglish
Pages (from-to)178-187
Number of pages10
JournalJournal of Human Hypertension
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • adolescence
  • blood pressure
  • omega-3
  • omega-6
  • polyunsaturated fatty acids
  • teenagers

Cite this