TY - JOUR
T1 - Polyphenols as prebiotics in the management of high-fat diet-induced obesity
T2 - A systematic review of animal studies
AU - Moorthy, Mohanambal
AU - Sundralingam, Usha
AU - Palanisamy, Uma D.
N1 - Funding Information:
Funding: This work was funded by the Ministry of Higher Education, FRGS/1/2017/SKK08/MUSM/ 02/2, and Tropical Medicine and Biology (TMB) Platform, Monash University. The APC was funded by Jeffrey Cheah School of Medicine, Monash University.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera Akkermansia, Bacteroides, Blautia, Roseburia, Bifidobacteria, Lactobacillus, Alistipes, and Desulfovibrio. Polyphenols’ anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.
AB - Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera Akkermansia, Bacteroides, Blautia, Roseburia, Bifidobacteria, Lactobacillus, Alistipes, and Desulfovibrio. Polyphenols’ anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.
KW - Anti-hyperglycaemic
KW - Anti-inflammatory
KW - Gut microbiota
KW - Obesity
KW - Polyphenols
KW - Prebiotics
UR - http://www.scopus.com/inward/record.url?scp=85103037787&partnerID=8YFLogxK
U2 - 10.3390/foods10020299
DO - 10.3390/foods10020299
M3 - Review Article
C2 - 33540692
AN - SCOPUS:85103037787
VL - 10
JO - Foods
JF - Foods
SN - 2304-8158
IS - 2
M1 - 299
ER -
