TY - JOUR
T1 - Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP)
T2 - Past, present and future
AU - Wibowo, Steven Harris
AU - Sulistio, Adrian
AU - Wong, Edgar Hoe Hon
AU - Blencowe, Anton
AU - Qiao, Greg
PY - 2014/5/21
Y1 - 2014/5/21
N2 - The formation of surface-grafted polypeptide films and interfaces via N-carboxyanhydride ring-opening polymerization (NCA-ROP) holds great potential for the facile preparation of next-generation multifunctional and responsive materials with excellent biocompatibility, biodegradability, tunable conformations and chemical functionalities. Therefore, the aim of this feature article is to provide a topical review of developments in the area of polypeptide films derived through NCA-ROP. It is evident that studies reported thus far have only started to unveil the full potential of peptide-based interfaces and materials, and with continued advancements it is anticipated that the strategic combination of NCA-ROP with modern synthetic chemistries will continue to yield versatile platforms for broader applications in the fields of polymer therapeutics, tissue engineering, (bio)nanocoatings, (bio)chemosensors, catalysis and separation technologies.
AB - The formation of surface-grafted polypeptide films and interfaces via N-carboxyanhydride ring-opening polymerization (NCA-ROP) holds great potential for the facile preparation of next-generation multifunctional and responsive materials with excellent biocompatibility, biodegradability, tunable conformations and chemical functionalities. Therefore, the aim of this feature article is to provide a topical review of developments in the area of polypeptide films derived through NCA-ROP. It is evident that studies reported thus far have only started to unveil the full potential of peptide-based interfaces and materials, and with continued advancements it is anticipated that the strategic combination of NCA-ROP with modern synthetic chemistries will continue to yield versatile platforms for broader applications in the fields of polymer therapeutics, tissue engineering, (bio)nanocoatings, (bio)chemosensors, catalysis and separation technologies.
UR - http://www.scopus.com/inward/record.url?scp=84898971415&partnerID=8YFLogxK
U2 - 10.1039/c4cc00293h
DO - 10.1039/c4cc00293h
M3 - Review Article
C2 - 24577357
AN - SCOPUS:84898971415
SN - 1359-7345
VL - 50
SP - 4971
EP - 4988
JO - Chemical Communications
JF - Chemical Communications
IS - 39
ER -