Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP): Past, present and future

Steven Harris Wibowo, Adrian Sulistio, Edgar Hoe Hon Wong, Anton Blencowe, Greg Qiao

Research output: Contribution to journalReview ArticleResearchpeer-review

53 Citations (Scopus)


The formation of surface-grafted polypeptide films and interfaces via N-carboxyanhydride ring-opening polymerization (NCA-ROP) holds great potential for the facile preparation of next-generation multifunctional and responsive materials with excellent biocompatibility, biodegradability, tunable conformations and chemical functionalities. Therefore, the aim of this feature article is to provide a topical review of developments in the area of polypeptide films derived through NCA-ROP. It is evident that studies reported thus far have only started to unveil the full potential of peptide-based interfaces and materials, and with continued advancements it is anticipated that the strategic combination of NCA-ROP with modern synthetic chemistries will continue to yield versatile platforms for broader applications in the fields of polymer therapeutics, tissue engineering, (bio)nanocoatings, (bio)chemosensors, catalysis and separation technologies.

Original languageEnglish
Pages (from-to)4971-4988
Number of pages18
JournalChemical Communications
Issue number39
Publication statusPublished - 21 May 2014
Externally publishedYes

Cite this