Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro

Lisa S McCoy; Kade Douglas Roberts; Roger Leigh Nation; Philip Thompson; Tony Velkov; Jian Li; Yitzhak Tor

doi:10.1002/cbic.201300496

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro

Lisa S McCoy, Kade Douglas Roberts, Roger Leigh Nation, Philip Thompson, Tony Velkov, Jian Li, Yitzhak Tor

Research output: Contribution to journal › Article › Other › peer-review

28 Citations (Scopus)

Abstract

Looking for targets: While the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A-sites, domains responsible for translational decoding. Polymyxin B, colistin and analogues also hinder eukaryotic translation in vitro. These new targets and effects might be partially responsible for the plethora of adverse effects by these potent bactericidal agents.

Original language	English
Pages (from-to)	2083 - 2086
Number of pages	4
Journal	ChemBioChem
Volume	14
Issue number	16
DOIs	https://doi.org/10.1002/cbic.201300496
Publication status	Published - 2013

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10.1002/cbic.201300496

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abstract = "Looking for targets: While the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A-sites, domains responsible for translational decoding. Polymyxin B, colistin and analogues also hinder eukaryotic translation in vitro. These new targets and effects might be partially responsible for the plethora of adverse effects by these potent bactericidal agents.",

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AU - McCoy, Lisa S

AU - Roberts, Kade Douglas

AU - Nation, Roger Leigh

AU - Thompson, Philip

AU - Velkov, Tony

AU - Li, Jian

AU - Tor, Yitzhak

PY - 2013

Y1 - 2013

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AB - Looking for targets: While the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A-sites, domains responsible for translational decoding. Polymyxin B, colistin and analogues also hinder eukaryotic translation in vitro. These new targets and effects might be partially responsible for the plethora of adverse effects by these potent bactericidal agents.

UR - http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300496/abstract

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VL - 14

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JO - ChemBioChem

JF - ChemBioChem

IS - 16

ER -

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro

Abstract

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