TY - JOUR
T1 - Polymorphisms of the resistin gene and their association with obesity and resistin levels in Malaysian Malays
AU - Apalasamy, Yamunah Devi
AU - Rampal, Sanjay
AU - Salim, Agus
AU - Moy, Foong Ming
AU - Su, Tin Tin
AU - Majid, Hazreen Abdul
AU - Bulgiba, Awang
AU - Mohamed, Zahurin
N1 - Funding Information:
This study was supported by research Grants HIR-MOHE E000049-20001 and FL009-2011. We would like to thank all the participants of this research.
Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/6/28
Y1 - 2015/6/28
N2 - Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine association between resistin levels with certain SNPs and haplotypes of RETN. A total of 631 Malaysian Malay subjects were included in this study and genotyping was carried out using Sequenom MassARRAY. There was no significant difference found in both allelic and genotype frequencies of each of the RETN SNPs between the obese and non-obese groups after Bonferroni correction. RETN rs34861192 and rs3219175 SNPs were significantly associated with log-resistin levels. The GG genotype carriers are found to have higher levels of log-resistin compared to A allele carriers. The RETN haplotypes (CAG, CGA and GA) were significantly associated with resistin levels. However, the haplotypes of the RETN gene were not associated with obesity. Resistin levels were not correlated to metabolic parameters such as body weight, waist circumference, body mass index, and lipid parameters. RETN SNPs and haplotypes are of apparent functional importance in the regulation of resistin levels but are not correlated with obesity and related markers.
AB - Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine association between resistin levels with certain SNPs and haplotypes of RETN. A total of 631 Malaysian Malay subjects were included in this study and genotyping was carried out using Sequenom MassARRAY. There was no significant difference found in both allelic and genotype frequencies of each of the RETN SNPs between the obese and non-obese groups after Bonferroni correction. RETN rs34861192 and rs3219175 SNPs were significantly associated with log-resistin levels. The GG genotype carriers are found to have higher levels of log-resistin compared to A allele carriers. The RETN haplotypes (CAG, CGA and GA) were significantly associated with resistin levels. However, the haplotypes of the RETN gene were not associated with obesity. Resistin levels were not correlated to metabolic parameters such as body weight, waist circumference, body mass index, and lipid parameters. RETN SNPs and haplotypes are of apparent functional importance in the regulation of resistin levels but are not correlated with obesity and related markers.
KW - BMI
KW - Body mass index
KW - Obesity haplotypes
KW - RETN
UR - http://www.scopus.com/inward/record.url?scp=84929687746&partnerID=8YFLogxK
U2 - 10.1007/s10528-015-9678-9
DO - 10.1007/s10528-015-9678-9
M3 - Article
C2 - 25991560
AN - SCOPUS:84929687746
SN - 0006-2928
VL - 53
SP - 120
EP - 131
JO - Biochemical Genetics
JF - Biochemical Genetics
IS - 4-6
ER -
