Polymorphisms in the DBH and DRD2 gene regions and smoking behavior

Maria Teresa M V Freire, Francine Z C Marques, Mara H. Hutz, Claiton H D Bau

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31 Citations (Scopus)

Abstract

The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and non-smoking controls (N = 112). Alcoholic and non-alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non-smoking controls. Individuals who had at least one DBH-1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume256
Issue number2
DOIs
Publication statusPublished - 1 Mar 2006
Externally publishedYes

Keywords

  • Alcoholism
  • Dependence
  • Dopamine
  • Nicotine

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