Abstract
The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and non-smoking controls (N = 112). Alcoholic and non-alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non-smoking controls. Individuals who had at least one DBH-1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.
Original language | English |
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Pages (from-to) | 93-97 |
Number of pages | 5 |
Journal | European Archives of Psychiatry and Clinical Neuroscience |
Volume | 256 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Mar 2006 |
Externally published | Yes |
Keywords
- Alcoholism
- Dependence
- Dopamine
- Nicotine