Polymerization induced self-assembly

tuning of morphology using ionic strength and pH

Dewen Zhou, Siming Dong, Rhiannon P Kuchel, Sebastien Perrier, Per B Zetterlund

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Investigations of RAFT dispersion polymerization-induced self-Assembly (PISA) of 2-hydroxypropyl methacrylate (HPMA) in water/methanol at 60 °C using a cationically charged macroRAFT agent as the stabilizer block, namely P(N,N-diethylaminoethyl methacrylate)-stat-poly((ethylene glycol) methyl ether methacrylate) (PDEAEMA-stat-PEGMA), have been conducted with a view to tune particle morphologies by manipulation of the pH and the ionic strength. Above the LCST (45 °C) of (PDEAEMA-stat-PEGMA), the system can only be conducted as a dispersion polymerization at sufficiently low pH such that the stabilizer block is sufficiently protonated to ensure solubility in the continuous phase. It is demonstrated (reported in the form of an extensive morphology diagram) that a range of morphologies including spherical particles, rods and vesicles can be accessed by adjustment of the pH (via addition of HCl) and the ionic strength (via the concentration of NaCl). A decrease in the charge density of the coronal stabilizer layer via an increase in the pH (less protonation) shifts the system towards higher order morphologies. At a given pH, an increase in ionic strength leads to more extensive charge screening, thus allowing formation of higher order morphologies.

Original languageEnglish
Pages (from-to)3082-3089
Number of pages8
JournalPolymer Chemistry
Volume8
Issue number20
DOIs
Publication statusPublished - 28 May 2017

Cite this

Zhou, D., Dong, S., Kuchel, R. P., Perrier, S., & Zetterlund, P. B. (2017). Polymerization induced self-assembly: tuning of morphology using ionic strength and pH. Polymer Chemistry, 8(20), 3082-3089. https://doi.org/10.1039/c7py00552k
Zhou, Dewen ; Dong, Siming ; Kuchel, Rhiannon P ; Perrier, Sebastien ; Zetterlund, Per B. / Polymerization induced self-assembly : tuning of morphology using ionic strength and pH. In: Polymer Chemistry. 2017 ; Vol. 8, No. 20. pp. 3082-3089.
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Zhou, D, Dong, S, Kuchel, RP, Perrier, S & Zetterlund, PB 2017, 'Polymerization induced self-assembly: tuning of morphology using ionic strength and pH', Polymer Chemistry, vol. 8, no. 20, pp. 3082-3089. https://doi.org/10.1039/c7py00552k

Polymerization induced self-assembly : tuning of morphology using ionic strength and pH. / Zhou, Dewen; Dong, Siming; Kuchel, Rhiannon P; Perrier, Sebastien; Zetterlund, Per B.

In: Polymer Chemistry, Vol. 8, No. 20, 28.05.2017, p. 3082-3089.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Zhou, Dewen

AU - Dong, Siming

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AU - Perrier, Sebastien

AU - Zetterlund, Per B

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