Polymerization-amplified optical DNA detection on porous silicon templates

Dirk Holthausen, Roshan B. Vasani, Steven J P McInnes, Amanda V. Ellis, Nicolas H. Voelcker

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17 Citations (Scopus)

Abstract

A porous silicon-based optical DNA sensor is described herein, which enables rapid DNA detection. The DNA sensor relies on the specificity of the DNA base pairing in conjunction with an interferometric optical signal amplification step based on polymer formation within the porous silicon layer to detect the DNA targets in a highly selective fashion. We demonstrate that it is possible to discriminate between DNA strands exhibiting even a single nucleotide mismatch using this sensor. 

Original languageEnglish
Pages (from-to)919-921
Number of pages3
JournalACS Macro Letters
Volume1
Issue number7
DOIs
Publication statusPublished - 2012
Externally publishedYes

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