Polymer capsules for plaque-targeted in vivo delivery

Joseph J. Richardson, Mei Y. Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S. Law, Christoph E. Hagemeyer, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.
Original languageEnglish
Pages (from-to)7703-7707
Number of pages5
JournalAdvanced Materials
Volume28
Issue number35
DOIs
Publication statusPublished - 21 Sep 2016

Keywords

  • click-chemistry
  • degradation
  • nanomedicine
  • polymer blends
  • templating

Cite this

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., ... Caruso, F. (2016). Polymer capsules for plaque-targeted in vivo delivery. Advanced Materials, 28(35), 7703-7707. https://doi.org/10.1002/adma.201601754
Richardson, Joseph J. ; Choy, Mei Y. ; Guo, Junling ; Liang, Kang ; Alt, Karen ; Ping, Yuan ; Cui, Jiwei ; Law, Lok S. ; Hagemeyer, Christoph E. ; Caruso, Frank. / Polymer capsules for plaque-targeted in vivo delivery. In: Advanced Materials. 2016 ; Vol. 28, No. 35. pp. 7703-7707.
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Richardson, JJ, Choy, MY, Guo, J, Liang, K, Alt, K, Ping, Y, Cui, J, Law, LS, Hagemeyer, CE & Caruso, F 2016, 'Polymer capsules for plaque-targeted in vivo delivery' Advanced Materials, vol. 28, no. 35, pp. 7703-7707. https://doi.org/10.1002/adma.201601754

Polymer capsules for plaque-targeted in vivo delivery. / Richardson, Joseph J.; Choy, Mei Y.; Guo, Junling; Liang, Kang; Alt, Karen; Ping, Yuan; Cui, Jiwei; Law, Lok S.; Hagemeyer, Christoph E.; Caruso, Frank.

In: Advanced Materials, Vol. 28, No. 35, 21.09.2016, p. 7703-7707.

Research output: Contribution to journalArticleResearchpeer-review

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Richardson JJ, Choy MY, Guo J, Liang K, Alt K, Ping Y et al. Polymer capsules for plaque-targeted in vivo delivery. Advanced Materials. 2016 Sep 21;28(35):7703-7707. https://doi.org/10.1002/adma.201601754