Polydiscamides B, C, and D ( 1- 3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
|Pages (from-to)||8 - 11|
|Number of pages||3|
|Journal||Journal of Natural Products|
|Publication status||Published - 2008|