Polydiscamides B-D from a marine sponge ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists

Yunjiang Feng, Anthony R Carroll, David M Pass, Julia Kate Archbold, Vicky M Avery, Ronald J Quinn

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28 Citations (Scopus)

Abstract

Polydiscamides B, C, and D ( 1- 3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
Original languageEnglish
Pages (from-to)8 - 11
Number of pages3
JournalJournal of Natural Products
Volume71
Publication statusPublished - 2008

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