TY - JOUR
T1 - Polydiscamides B-D from a marine sponge ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists
AU - Feng, Yunjiang
AU - Carroll, Anthony R
AU - Pass, David M
AU - Archbold, Julia Kate
AU - Avery, Vicky M
AU - Quinn, Ronald J
PY - 2008
Y1 - 2008
N2 - Polydiscamides B, C, and D ( 1- 3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
AB - Polydiscamides B, C, and D ( 1- 3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18163586
M3 - Article
VL - 71
SP - 8
EP - 11
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
ER -
