TY - JOUR
T1 - Polycystic ovary syndrome and anti-Müllerian hormone
T2 - Role of insulin resistance, androgens, obesity and gonadotrophins
AU - Cassar, Samantha
AU - Teede, Helena Jane
AU - Moran, Lisa Jane
AU - Joham, Anju Elizabeth
AU - Harrison, Cheryce Lee
AU - Strauss, Boyd Josef Gimnicher
AU - Stepto, Nigel Keith
PY - 2014
Y1 - 2014
N2 - Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder associated with insulin resistance, hyperandrogenism, obesity, altered gonadotrophin release and anovulatory infertility. Anti-Mullerian hormone (AMH) has been proposed as a marker of ovarian function and fertility. Across a cohort of lean and overweight women with and without PCOS, we investigated the association of AMH with insulin resistance and body composition using gold standard measures. A secondary aim was to examine whether AMH was useful to determine PCOS status. Design: Cross-sectional study. Patients: A total of 22 lean and 21 overweight women with PCOS and 19 lean and 16 overweight non-PCOS healthy controls were recruited. PCOS was diagnosed based on the Rotterdam criteria. Measurements: Euglycaemic-hyperinsulinaemic clamp for assessing insulin resistance, dual energy X-ray absorptiometry and computed tomography for assessing adiposity, and blood sampling for the assessment of androgens, gonadotrophins and AMH. Results: Anti-Mullerian hormone levels were increased in women with PCOS (P
AB - Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder associated with insulin resistance, hyperandrogenism, obesity, altered gonadotrophin release and anovulatory infertility. Anti-Mullerian hormone (AMH) has been proposed as a marker of ovarian function and fertility. Across a cohort of lean and overweight women with and without PCOS, we investigated the association of AMH with insulin resistance and body composition using gold standard measures. A secondary aim was to examine whether AMH was useful to determine PCOS status. Design: Cross-sectional study. Patients: A total of 22 lean and 21 overweight women with PCOS and 19 lean and 16 overweight non-PCOS healthy controls were recruited. PCOS was diagnosed based on the Rotterdam criteria. Measurements: Euglycaemic-hyperinsulinaemic clamp for assessing insulin resistance, dual energy X-ray absorptiometry and computed tomography for assessing adiposity, and blood sampling for the assessment of androgens, gonadotrophins and AMH. Results: Anti-Mullerian hormone levels were increased in women with PCOS (P
UR - http://www.scopus.com/inward/record.url?scp=84912075093&partnerID=8YFLogxK
U2 - 10.1111/cen.12557
DO - 10.1111/cen.12557
M3 - Article
SN - 0300-0664
VL - 81
SP - 899
EP - 906
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 6
ER -
