Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice

Mahnaz Bahri Khomami, Jacqueline A. Boyle, Chau T. Tay, Eszter Vanky, Helena J. Teede, Anju E. Joham, Lisa J. Moran

Research output: Contribution to journalReview ArticleOtherpeer-review

16 Citations (Scopus)


Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications.

Original languageEnglish
Pages (from-to)761-769
Number of pages9
JournalClinical Endocrinology
Issue number6
Publication statusPublished - 1 Jun 2018


  • hyperandrogenism
  • obesity
  • obstetric labour complications
  • polycystic ovary syndrome
  • pregnancy
  • pregnancy complications
  • prenatal care

Cite this