Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia

Sebastiaan J. van Hal, Björn A. Espedido, Geoffrey W. Coombs, Benjamin P. Howden, Tony M. Korman, Graeme R. Nimmo, Iain B. Gosbell, Slade O. Jensen

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20 Citations (Scopus)

Abstract

Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.

Original languageEnglish
Pages (from-to)998-1001
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume72
Issue number4
DOIs
Publication statusPublished - 2017
Externally publishedYes

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