Polyandric acid A, a clerodane diterpenoid from the Australian medicinal plant Dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo

Bradley S Simpson, Xianling Luo, Maurizio Costabile, Gillian E Caughey, Jiping Wang, David J Claudie, Ross A McKinnon, Susan J Semple

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Abstract

Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1? production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis.
Original languageEnglish
Pages (from-to)85 - 91
Number of pages7
JournalJournal of Natural Products
Volume77
Issue number1
DOIs
Publication statusPublished - 2014

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