Poly(2-oxazoline)-based micro- and nanoparticles: a review

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Poly(2-oxazoline)s (POx) are a class of polymers with tremendous potential for biomedical applications. The straightforward access to side and main chain functionalities by selecting suitable monomers and initiators/terminating agents, respectively, in combination with the biocompatibility, stealth and protein repellent properties of their water-soluble homologues enables the fabrication of highly functional POx materials. Post polymerisation modifications of POx further increase this toolbox and allow to merge their properties with the ones of other polymer classes. This review describes nano- and microscale POx particulate materials available to date with particular focus on macromolecular design of the polymers used for the individual formulation techniques. Amongst others, microparticles, microspheres, hollow layer-by-layer microcapsules as well as nanoparticles, micelles, polymersomes, nanogels and POx coated inorganic nanoparticles will be discussed.

Original languageEnglish
Pages (from-to)486-515
Number of pages30
JournalEuropean Polymer Journal
Volume88
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Block copolymer
  • Micelle
  • Nanogel
  • Particle
  • Poly(2-oxazoline)
  • Vesicle

Cite this

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title = "Poly(2-oxazoline)-based micro- and nanoparticles: a review",
abstract = "Poly(2-oxazoline)s (POx) are a class of polymers with tremendous potential for biomedical applications. The straightforward access to side and main chain functionalities by selecting suitable monomers and initiators/terminating agents, respectively, in combination with the biocompatibility, stealth and protein repellent properties of their water-soluble homologues enables the fabrication of highly functional POx materials. Post polymerisation modifications of POx further increase this toolbox and allow to merge their properties with the ones of other polymer classes. This review describes nano- and microscale POx particulate materials available to date with particular focus on macromolecular design of the polymers used for the individual formulation techniques. Amongst others, microparticles, microspheres, hollow layer-by-layer microcapsules as well as nanoparticles, micelles, polymersomes, nanogels and POx coated inorganic nanoparticles will be discussed.",
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author = "Paul Wilson and Ke, {Pu Chun} and Davis, {Thomas P.} and Kristian Kempe",
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Poly(2-oxazoline)-based micro- and nanoparticles : a review. / Wilson, Paul; Ke, Pu Chun; Davis, Thomas P.; Kempe, Kristian.

In: European Polymer Journal, Vol. 88, 01.03.2017, p. 486-515.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - a review

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AU - Ke, Pu Chun

AU - Davis, Thomas P.

AU - Kempe, Kristian

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KW - Vesicle

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