POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report

Abstract Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes are often the presenting features of the POEMS syndrome. Approximately 50% of these are associated with osteosclerotic myeloma, a rare variant of multiple myeloma and some with Castlemanapos;s disease, an unusual lympho‐proliferative disorder. The underlying pathogenetic mechanisms have not been elucidated but amelioration of symptoms with the disappearance of the M‐component suggests possible etiopathogenic mechanisms. We present a 40‐year‐old woman with manifestations of all three disorders. (Aust NZ J Med 1991; 21:454–456.).