Pneumococcal vaccines for allergic airways diseases

Alison Thorburn, Phillip M Hansbro, Peter G Gibson

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

BACKGROUND: Asthma is a common global health problem. Environmental exposures such as bacteria may protect against asthma development. OBJECTIVE: This review aims to examine the possible protective role of pneumococcal infection and vaccination in asthma. METHODS: A review of known experimental biology and human epidemiology relating to asthma and pneumococcal infection was performed. RESULTS: Pneumococcal infection can modulate components of allergic airways disease such as airways hyperresponsiveness and airway eosinophilia. Exposure to killed pneumococcus can reproduce these effects and the mechanism may involve control by T regulatory cells. CONCLUSIONS: Pneumococcal immunoregulatory therapy is a potentially important approach to asthma management that requires further evaluation in well-designed research studies.
Original languageEnglish
Pages (from-to)621 - 629
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume9
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

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