Pluripotent stem cell-based models to investigate retinal pigmented epithelium function and disease

Duncan E. Crombie; Alice Pébay; Robyn H. Guymer; Kathryn C. Davidson

doi:10.1016/j.ddmod.2014.02.010

Pluripotent stem cell-based models to investigate retinal pigmented epithelium function and disease

Duncan E. Crombie
, Alice Pébay
, Robyn H. Guymer
, Kathryn C. Davidson

Research output: Contribution to journal › Review Article › Research › peer-review

Abstract

Animal models do not always recapitulate or translate to human diseases. Pluripotent stem cells provide a self-renewing resource to generate mature cell types, including those of the retina. Furthermore, induced pluripotent stem cells derived from patients with genetic diseases can be differentiated into specialized cells to create in vitro disease models with precise pathogenic genotypes. Recent progress in deriving functional RPE cells from these disease-carrying stem cells in vitro can provide insights into disease pathobiology, thus providing a platform for discovery of new pharmacological interventions.

Original language	English
Pages (from-to)	e231-e236
Journal	Drug Discovery Today: Disease Models
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmod.2014.02.010
Publication status	Published - 4 Feb 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ddmod.2014.02.010

Cite this

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abstract = "Animal models do not always recapitulate or translate to human diseases. Pluripotent stem cells provide a self-renewing resource to generate mature cell types, including those of the retina. Furthermore, induced pluripotent stem cells derived from patients with genetic diseases can be differentiated into specialized cells to create in vitro disease models with precise pathogenic genotypes. Recent progress in deriving functional RPE cells from these disease-carrying stem cells in vitro can provide insights into disease pathobiology, thus providing a platform for discovery of new pharmacological interventions.",

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AU - Guymer, Robyn H.

AU - Davidson, Kathryn C.

PY - 2013/2/4

Y1 - 2013/2/4

N2 - Animal models do not always recapitulate or translate to human diseases. Pluripotent stem cells provide a self-renewing resource to generate mature cell types, including those of the retina. Furthermore, induced pluripotent stem cells derived from patients with genetic diseases can be differentiated into specialized cells to create in vitro disease models with precise pathogenic genotypes. Recent progress in deriving functional RPE cells from these disease-carrying stem cells in vitro can provide insights into disease pathobiology, thus providing a platform for discovery of new pharmacological interventions.

AB - Animal models do not always recapitulate or translate to human diseases. Pluripotent stem cells provide a self-renewing resource to generate mature cell types, including those of the retina. Furthermore, induced pluripotent stem cells derived from patients with genetic diseases can be differentiated into specialized cells to create in vitro disease models with precise pathogenic genotypes. Recent progress in deriving functional RPE cells from these disease-carrying stem cells in vitro can provide insights into disease pathobiology, thus providing a platform for discovery of new pharmacological interventions.

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M3 - Review Article

AN - SCOPUS:84901382872

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JO - Drug Discovery Today: Disease Models

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ER -

Pluripotent stem cell-based models to investigate retinal pigmented epithelium function and disease

Abstract

UN SDGs

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