Platinum(IV) organometallics I. Syntheses of trans-di(carboxylato)ethane-1,2-diamine-cis-bis(pentafluoro-phenyl)plati num(IV) complexes and the X-ray crystal structure of the n-butanoato derivative

G. B. Deacon, E. T. Lawrenz, T. W. Hambley, S. Rainone, L. K. Webster

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Abstract

The complex Pt(C6F5)2(OH)2(en) (en = ethane-1,2-diamine) has been prepared by oxidation of Pt(C6F5)2(en) hydrogen peroxide in acetone. Treatment of the platinum(IV) complex with acid anhydrides, (RCO)2O (R = Me, Et, nPr, or iPr), in ether yields cis, trans-Pt(C6F5)2(O2CR) 2(en) complexes. The stereochemistry was established by an X-ray diffraction study of Pt(C6F5)2(O2CnPr) 2(en), which has an octahedral arrangement involving trans unidentate butanoate ligands and cis-C6F5 groups, and by spectroscopic similarities between the complexes. There is hydrogen bonding between uncoordinated carboxyl oxygens and NH groups, and between one ortho-fluorine of each C6F5 group and an NH group. The 19F NMR spectra show five fluorine resonances at -50 °C, indicative of unsymmetrical C6F5 groups with restricted rotation, and this is consistent with features of the solid state structure of cis, trans-Pr(C6F5)2(O2Cn Pr)2(en). Preliminary examination of the biological activity of the complexes against L1210 and L1210/DDP mouse leukemia cells in culture has been made.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalJournal of Organometallic Chemistry
Volume493
Issue number1-2
Publication statusPublished - 17 May 1995

Keywords

  • Antitumour activity
  • Carbonylate complexes
  • Crystal structure
  • Diamine complexes
  • Pentafluorophenyl
  • Platinum

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