The complex Pt(C6F5)2(OH)2(en) (en = ethane-1,2-diamine) has been prepared by oxidation of Pt(C6F5)2(en) hydrogen peroxide in acetone. Treatment of the platinum(IV) complex with acid anhydrides, (RCO)2O (R = Me, Et, nPr, or iPr), in ether yields cis, trans-Pt(C6F5)2(O2CR) 2(en) complexes. The stereochemistry was established by an X-ray diffraction study of Pt(C6F5)2(O2CnPr) 2(en), which has an octahedral arrangement involving trans unidentate butanoate ligands and cis-C6F5 groups, and by spectroscopic similarities between the complexes. There is hydrogen bonding between uncoordinated carboxyl oxygens and NH groups, and between one ortho-fluorine of each C6F5 group and an NH group. The 19F NMR spectra show five fluorine resonances at -50 °C, indicative of unsymmetrical C6F5 groups with restricted rotation, and this is consistent with features of the solid state structure of cis, trans-Pr(C6F5)2(O2Cn Pr)2(en). Preliminary examination of the biological activity of the complexes against L1210 and L1210/DDP mouse leukemia cells in culture has been made.
|Number of pages||9|
|Journal||Journal of Organometallic Chemistry|
|Publication status||Published - 17 May 1995|
- Antitumour activity
- Carbonylate complexes
- Crystal structure
- Diamine complexes