Platelet-VWF complexes get the chop

Michael C. Berndt, Robert K. Andrews

Research output: Contribution to journalShort SurveyOtherpeer-review


In this issue of Blood, Shim and colleagues define a dual role for platelet glycoprotein (GP)Ibα (the major ligand-binding subunit of the GPIb-IX-V complex) in regulating ADAMTS13-mediated cleavage of von Willebrand factor (VWF) under shear: it alleviates an inhibitory effect of the VWFA1 domain on cleavage of the A2 domain, 1 and it allows tensile force to be exerted on the A2 domain through at least 2 platelets binding per VWF multimer via the A1 domain (see figure).

Original languageEnglish
Number of pages1
Issue number2
Publication statusPublished - 15 Jan 2008

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