Abstract
1. The uptake of [3H]dopamine was measured using platelet-rich plasma (PRP) from neuroleptic- free subjects and again, in some cases, after the subject had been treated with neuroleptic drugs. 2. There were no differences in [3H]dopamine uptake by PRP in subjects who were or were not mentally ill. 3. After treatment with neuroleptic drugs the Km for platelet [3H]dopamine uptake had increased in 76% of subjects with schizophrenia and 87% of subjects with schizophreniform disorder. Similarly, the Vmax for platelet [3H]dopamine uptake had increased in 81% of the subjects with schizophrenia and 86% of the subjects with schizophreniform disorder. 4. By contrast, the Km for platelet [3H]dopamine uptake had decreased in 94% of subjects who had a psychoses associated with an illness other than schizophrenia or schizophreniform disorder whilst the Vmax for platelet [3H]dopamine uptake also decreased by 94% in these subjects. 5. In subjects with psychoses, platelet [3H]dopamine uptake is differentially altered during euroleptic drug treatment depending on diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 45-55 |
| Number of pages | 11 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 1996 |
| Externally published | Yes |
Keywords
- Dopamine
- Neuroleptic drugs
- Platelet
- Schizophrenia
Cite this
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Platelet [3H]dopamine uptake is differentially affected by neuroleptic drug treatment in schizophrenia and schizophreniform disorder. / Dean, Brian; Sundram, Suresh; Hill, Christine; Copolov, David L.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 20, No. 1, 01.01.1996, p. 45-55.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Platelet [3H]dopamine uptake is differentially affected by neuroleptic drug treatment in schizophrenia and schizophreniform disorder
AU - Dean, Brian
AU - Sundram, Suresh
AU - Hill, Christine
AU - Copolov, David L.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - 1. The uptake of [3H]dopamine was measured using platelet-rich plasma (PRP) from neuroleptic- free subjects and again, in some cases, after the subject had been treated with neuroleptic drugs. 2. There were no differences in [3H]dopamine uptake by PRP in subjects who were or were not mentally ill. 3. After treatment with neuroleptic drugs the Km for platelet [3H]dopamine uptake had increased in 76% of subjects with schizophrenia and 87% of subjects with schizophreniform disorder. Similarly, the Vmax for platelet [3H]dopamine uptake had increased in 81% of the subjects with schizophrenia and 86% of the subjects with schizophreniform disorder. 4. By contrast, the Km for platelet [3H]dopamine uptake had decreased in 94% of subjects who had a psychoses associated with an illness other than schizophrenia or schizophreniform disorder whilst the Vmax for platelet [3H]dopamine uptake also decreased by 94% in these subjects. 5. In subjects with psychoses, platelet [3H]dopamine uptake is differentially altered during euroleptic drug treatment depending on diagnosis.
AB - 1. The uptake of [3H]dopamine was measured using platelet-rich plasma (PRP) from neuroleptic- free subjects and again, in some cases, after the subject had been treated with neuroleptic drugs. 2. There were no differences in [3H]dopamine uptake by PRP in subjects who were or were not mentally ill. 3. After treatment with neuroleptic drugs the Km for platelet [3H]dopamine uptake had increased in 76% of subjects with schizophrenia and 87% of subjects with schizophreniform disorder. Similarly, the Vmax for platelet [3H]dopamine uptake had increased in 81% of the subjects with schizophrenia and 86% of the subjects with schizophreniform disorder. 4. By contrast, the Km for platelet [3H]dopamine uptake had decreased in 94% of subjects who had a psychoses associated with an illness other than schizophrenia or schizophreniform disorder whilst the Vmax for platelet [3H]dopamine uptake also decreased by 94% in these subjects. 5. In subjects with psychoses, platelet [3H]dopamine uptake is differentially altered during euroleptic drug treatment depending on diagnosis.
KW - Dopamine
KW - Neuroleptic drugs
KW - Platelet
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0029658101&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(95)00291-X
DO - 10.1016/0278-5846(95)00291-X
M3 - Article
C2 - 8861176
AN - SCOPUS:0029658101
VL - 20
SP - 45
EP - 55
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 1
ER -