Plasmonic caged gold nanorods for near-infrared light controlled drug delivery

Wei Xiong, Romiza Rehana Mazid, Lim Wei Yap, Xinyong Li, Wenlong Cheng

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A new near-infrared light-controlled drug delivery system based on caged gold nanorods (CGNRs) is demonstrated. The loading and release process of drug payloads into/from CGNR nanocarriers were systematically investigated. The drug-loaded CGNR constructs could enable combined chemotherapy and photo-thermal effects in killing tumor cells upon light irradiation, therefore, enhance the killing efficiency. In conjunction with visibility under quenching-free dark-field imaging, CGNRs may serve as multifunctional theranostic reagents towards cancer diagnostics and therapeutics.
Original languageEnglish
Pages (from-to)14388 - 14393
Number of pages6
JournalNanoscale
Volume6
Issue number23
DOIs
Publication statusPublished - 2014

Cite this

Xiong, Wei ; Mazid, Romiza Rehana ; Yap, Lim Wei ; Li, Xinyong ; Cheng, Wenlong. / Plasmonic caged gold nanorods for near-infrared light controlled drug delivery. In: Nanoscale. 2014 ; Vol. 6, No. 23. pp. 14388 - 14393.
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Plasmonic caged gold nanorods for near-infrared light controlled drug delivery. / Xiong, Wei; Mazid, Romiza Rehana; Yap, Lim Wei; Li, Xinyong; Cheng, Wenlong.

In: Nanoscale, Vol. 6, No. 23, 2014, p. 14388 - 14393.

Research output: Contribution to journalArticleResearchpeer-review

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AB - A new near-infrared light-controlled drug delivery system based on caged gold nanorods (CGNRs) is demonstrated. The loading and release process of drug payloads into/from CGNR nanocarriers were systematically investigated. The drug-loaded CGNR constructs could enable combined chemotherapy and photo-thermal effects in killing tumor cells upon light irradiation, therefore, enhance the killing efficiency. In conjunction with visibility under quenching-free dark-field imaging, CGNRs may serve as multifunctional theranostic reagents towards cancer diagnostics and therapeutics.

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