TY - JOUR
T1 - Plasmodium vivax vaccine research – we've only just begun
AU - Tham, Wai Hong
AU - Beeson, James G.
AU - Rayner, Julian C
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause of severe disease. The unique attributes of P. vivax biology, particularly the capacity of the dormant liver stage, the hypnozoite, to maintain blood-stage infections even in the absence of active transmission, make blood-stage vaccines particularly attractive for this species. However, P. vivax vaccine development remains resolutely in first gear, with only a single blood-stage candidate having been evaluated in any depth. Experience with Plasmodium falciparum suggests that a much broader search for new candidates and a deeper understanding of high priority targets will be required to make significant advances. This review discusses some of the particular challenges of P. vivax blood-stage vaccine development, highlighting both recent advances and key remaining barriers to overcome in order to move development forward.
AB - Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause of severe disease. The unique attributes of P. vivax biology, particularly the capacity of the dormant liver stage, the hypnozoite, to maintain blood-stage infections even in the absence of active transmission, make blood-stage vaccines particularly attractive for this species. However, P. vivax vaccine development remains resolutely in first gear, with only a single blood-stage candidate having been evaluated in any depth. Experience with Plasmodium falciparum suggests that a much broader search for new candidates and a deeper understanding of high priority targets will be required to make significant advances. This review discusses some of the particular challenges of P. vivax blood-stage vaccine development, highlighting both recent advances and key remaining barriers to overcome in order to move development forward.
KW - Erythrocyte invasion
KW - Malaria
KW - Plasmodium vivax
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85007571953&partnerID=8YFLogxK
U2 - 10.1016/j.ijpara.2016.09.006
DO - 10.1016/j.ijpara.2016.09.006
M3 - Article
AN - SCOPUS:85007571953
SN - 0020-7519
VL - 47
SP - 111
EP - 118
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 2-3
ER -