Plasmodium falciparum: Comparative analysis of erythrocyte stage-dependent protein antigens

Graham V. Brown, Ross L. Coppel, Helena Vrbova, Raelene J. Grumont, Robin F. Anders

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Abstract

Proteins of erythrocytic stages of Plasmodium falciparum were biosynthetically labeled at different times during the first cycle of in vitro synchronous cultivation after collection from patients in the Madang region of Papua New Guinea. Proteins were immunoprecipitated with a pool of hyperimmune serum collected in the region then analyzed by sodium dodecyl sulfate-gel electrophoresis. Antigens were recognized in all life cycle stages but the majority of antigens, particularly those of high molecular weight, were present in the mature forms of the parasite.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalExperimental Parasitology
Volume53
Issue number2
DOIs
Publication statusPublished - 1 Jan 1982
Externally publishedYes

Keywords

  • Antigens
  • Biosynthetic labeling
  • Blood stages
  • Cultivation
  • Hyperimmune sera, human
  • Malaria, human
  • Plasmodium falciparum
  • Protozoa, parasitic

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