Plasminogen activator inhibitor 2: Regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells

W. D. Schleuning, R. L. Medcalf, C. Hession, R. Rothenbuhler, A. Shaw, E. K.O. Kruithof

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Abstract

We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

Original languageEnglish
Pages (from-to)4564-4567
Number of pages4
JournalMolecular and Cellular Biology
Volume7
Issue number12
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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