Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?

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Abstract

Plasmin, the principal downstream product of tissue-type plasminogen activator (tPA), is known for its potent fibrin-degrading capacity but is also recognized for many non-fibrinolytic activities. Curiously, plasmin has not been conclusively linked to blood-brain barrier (BBB) disruption during recombinant tPA (rtPA)-induced thrombolysis in ischemic stroke. This is surprising given the substantial involvement of tPA in the modulation of BBB permeability and the co-existence of tPA and plasminogen in both blood and brain throughout the ischemic event. Here, we review the work that argues a role for plasmin together with endogenous tPA or rtPA in BBB alteration, presenting the overall controversy around the topic yet creating a rational case for an involvement of plasmin in this process
Original languageEnglish
Pages (from-to)1283 - 1296
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number8
DOIs
Publication statusPublished - 2014

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