Plasmid Incidence Rate and Conjugative Chloramphenicol and Tetracycline Resistance Plasmids in Malaysian Isolates of Salmonella typhi

Maude Phipps, Tikki Pang, Chong Lek Koh, Savithri Puthucheary

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Seven (6.1%) of 115 strains of Salmonella typhi isolated from Malaysian patients harbored a single large plasmid of 71 to 166 mD. Two of the seven plasmid-bearing strains were resistant to chloramphenicol (Cm) and tetracycline (Tc) and they transferred Cm and Tc resistance traits to Escherichia coli K12 at frequencies from 1.6 X 10 7 to 1.9 x 10 6. Agarose gel electrophoresis provided evidence that the resistance traits were cotransferred on a conjugative plasmid. The significance and importance of these results are discussed.

Original languageEnglish
Pages (from-to)1073-1084
Number of pages12
JournalMicrobiology and Immunology
Issue number2
Publication statusPublished - 1991
Externally publishedYes

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