Plasmid-encoded resistance to acriflavine and quaternary ammonium compounds in methicillin-resistant Staphylococcus aureus

M. T. Gillespie, J. W. May, R. A. Skurray

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The determinant for resistance to the antiseptics acriflavine, benzalkonium chloride and cetrimide and the intercalating dye, ethidium bromide has been physically mapped on pSK57, a penicillinase plasmid detected in strains of methicillin-resistant Staphylococcus aureus. Restriction endonuclease analysis and DNA-DNA hybridization indicate that this determinant is identical to that which encodes these resistances on the plasmid pSK1, which is the most frequently detected gentamicin resistance plasmid in methicillin-resistant S. aureus isolates from Australian hospitals.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalFEMS Microbiology Letters
Issue number1
Publication statusPublished - 1 Jan 1986


  • Aminoglycosides
  • antiseptics
  • penicillin
  • resistance plasmids

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