Plasma total-tau as a biomarker of stroke risk in the community

Matthew P. Pase; Jayandra J. Himali; Hugo J. Aparicio; Jose Rafael Romero; Claudia L. Satizabal; Pauline Maillard; Charles DeCarli; Alexa S. Beiser; Sudha Seshadri

doi:10.1002/ana.25542

Plasma total-tau as a biomarker of stroke risk in the community

Matthew P. Pase, Jayandra J. Himali, Hugo J. Aparicio, Jose Rafael Romero, Claudia L. Satizabal, Pauline Maillard, Charles DeCarli, Alexa S. Beiser, Sudha Seshadri

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.

Original language	English
Pages (from-to)	463-467
Number of pages	5
Journal	Annals of Neurology
Volume	86
Issue number	3
DOIs	https://doi.org/10.1002/ana.25542
Publication status	Published - Sept 2019
Externally published	Yes

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title = "Plasma total-tau as a biomarker of stroke risk in the community",

abstract = "Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95\% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.",

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T1 - Plasma total-tau as a biomarker of stroke risk in the community

AU - Pase, Matthew P.

AU - Himali, Jayandra J.

AU - Aparicio, Hugo J.

AU - Romero, Jose Rafael

AU - Satizabal, Claudia L.

AU - Maillard, Pauline

AU - DeCarli, Charles

AU - Beiser, Alexa S.

AU - Seshadri, Sudha

PY - 2019/9

Y1 - 2019/9

N2 - Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.

AB - Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.

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SN - 0364-5134

VL - 86

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EP - 467

JO - Annals of Neurology

JF - Annals of Neurology

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Plasma total-tau as a biomarker of stroke risk in the community

Abstract

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